An update–tissue engineered nerve grafts for the repair of peripheral nerve injuries
نویسندگان
چکیده
منابع مشابه
Engineered neural tissue for peripheral nerve repair.
A new combination of tissue engineering techniques provides a simple and effective method for building aligned cellular biomaterials. Self-alignment of Schwann cells within a tethered type-1 collagen matrix, followed by removal of interstitial fluid produces a stable tissue-like biomaterial that recreates the aligned cellular and extracellular matrix architecture associated with nerve grafts. S...
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Acellular nerve allografts can help preserve normal nerve structure and extracellular matrix composition. These allografts have low immunogenicity and are more readily available than autologous nerves for the repair of long-segment peripheral nerve defects. In this study, we repaired a 40-mm ulnar nerve defect in rhesus monkeys with tissue-engineered peripheral nerve, and compared the outcome w...
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With advances in biomedical methods, tissue-engineered materials have developed rapidly as an alternative to nerve autografts for the repair of peripheral nerve injuries. However, the materials selected for use in the repair of peripheral nerve injuries, in particular multiple injuries and large-gap defects, must be chosen carefully. Various methods and materials for protecting the healthy tiss...
متن کاملA 3D-engineered porous conduit for peripheral nerve repair
End-to-end neurorrhaphy is the most commonly used method for treating peripheral nerve injury. However, only 50% of patients can regain useful function after treating with neurorrhaphy. Here, we constructed a 3D-engineered porous conduit to promote the function recovery of the transected peripheral nerve after neurorrhaphy. The conduit that consisted of a gelatin cryogel was prepared by molding...
متن کاملTissue-engineered Peripheral Nerve
Nerve injuries occur by a variety of mechanisms, including traumatic wounds, thermal or chemical damage, myelin or axonal degeneration, and acute compression. These injuries typically result in the loss of motor function, sensory function, or both. Functional recovery is regained upon complete axonal regeneration, which includes remyelination and reinnervation (i.e., synapse formation) of the a...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2018
ISSN: 1673-5374
DOI: 10.4103/1673-5374.232458